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Article

Deletion of two growth-factor repeats from the low-density-lipoprotein receptor accelerates its degradation.

The Biochemical journal - 1 Aug 1991

van der Westhuyzen D R, Stein M L, Henderson H E, Marais A D, Fourie A M, Coetzee G A

Abstract excerpt

The region of the low-density-lipoprotein (LDL) receptor showing sequence similarity to the epidermal-growth-factor (EGF) precursor is required for LDL binding and the acid-induced dissociation of ligand and receptor. We describe here a naturally occurring mutant LDL receptor, found in a patient with homozygous familial hypercholesterolaemia, which lacks the first two growth-factor-like repeats of the...

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Identifiers

PMID: 1872803
DOI: 10.1042/bj2770677
PMCID: PMC1151296

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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