Deletion of two growth-factor repeats from the low-density-lipoprotein receptor accelerates its degradation.

doi:10.1042/bj2770677

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Article

Deletion of two growth-factor repeats from the low-density-lipoprotein receptor accelerates its degradation.

The Biochemical journal - 1 Aug 1991

van der Westhuyzen D R, Stein M L, Henderson H E, Marais A D, Fourie A M, Coetzee G A

Abstract excerpt

The region of the low-density-lipoprotein (LDL) receptor showing sequence similarity to the epidermal-growth-factor (EGF) precursor is required for LDL binding and the acid-induced dissociation of ligand and receptor. We describe here a naturally occurring mutant LDL receptor, found in a patient with homozygous familial hypercholesterolaemia, which lacks the first two growth-factor-like repeats of the...

Topics

Adolescent
Apolipoproteins E
Base Sequence
Blotting, Southern
Chromosome Deletion
Female
Humans
Hyperlipoproteinemia Type II
Lipoproteins, LDL
Lipoproteins, VLDL
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligonucleotides

Polymerase Chain Reaction

Receptors, LDL

Restriction Mapping

Structure-Activity Relationship

Source

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Identifiers

PMID: 1872803
DOI: 10.1042/bj2770677
PMCID: PMC1151296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1872803-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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