Article
Involvement of the conserved acidic amino acid domain of FGF receptor 1 in ligand-receptor interaction.
Journal of cellular physiology - 1 Nov 1993
Chaudhuri M M, Moscatelli D, Basilico C
Abstract excerpt
The fibroblast growth factor receptor 1 (flg) contains eight acidic amino acids between the first and second immunoglobulin domain. This report examines the role of the acidic domain in the interaction of the flg receptor with its ligands. We observed a marked inhibition of binding of bFGF to the...
Topics
- Amino Acid Sequence
- Amino Acids
- Animals
- CHO Cells
- Cricetinae
- DNA
- Electrophoresis, Polyacrylamide Gel
- Fibroblast Growth Factor 2
- Ligands
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Precipitin Tests
- Protein Binding
- Receptor Protein-Tyrosine Kinases
- Receptor, Fibroblast Growth Factor, Type 1
- Receptors, Fibroblast Growth Factor
- Transfection