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Article

Involvement of the conserved acidic amino acid domain of FGF receptor 1 in ligand-receptor interaction.

Journal of cellular physiology - 1 Nov 1993

Chaudhuri M M, Moscatelli D, Basilico C

Abstract excerpt

The fibroblast growth factor receptor 1 (flg) contains eight acidic amino acids between the first and second immunoglobulin domain. This report examines the role of the acidic domain in the interaction of the flg receptor with its ligands. We observed a marked inhibition of binding of bFGF to the receptor when the acidic domain was completely deleted, but mutants with two and four amino acids deleted (flg delta...

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PMID: 8227155
DOI: 10.1002/jcp.1041570202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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