Article
Activation of phospholipase D in human fibroblasts by ceramide and sphingosine: evaluation of their modulatory role in bradykinin stimulation of phospholipase D.
Biochemical and biophysical research communications - 14 Aug 1996
Meacci E, Vasta V, Neri S, Farnararo M, Bruni P
Abstract excerpt
In the present study the modulatory action of exogenous short-chain ceramide and sphingosine on phospholipase D (PLD) activity in young and old human fibroblasts was examined. Sphingosine and also ceramide, thus far described as a negative modulator of PLD, were able to activate PLD. The stimulatory action of the exogenous lipid molecules was mimicked by cell treatment with S.aureus sphingomyelinase (SMase)....
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