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Article

Turnover of endogenous ceramide in cultured normal and Farber fibroblasts.

Journal of lipid research - 1 Dec 1997

van Echten-Deckert G, Klein A, Linke T, Heinemann T, Weisgerber J, Sandhoff K

Abstract excerpt

De novo synthesis and turnover of endogenous ceramide in cultured skin fibroblasts from patients affected with Farber lipogranulomatosis were studied by biosynthetical labeling of cellular sphingolipids with [14C]serine. The cellular uptake of [14C]serine and incorporation into de novo synthesized ceramide was similar in normal and Farber fibroblasts, with a half life of newly synthesized ceramide of 2.7 h in...

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PMID: 9458280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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