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Article

Identification and characterization of yeast mutants that overcome an experimentally introduced block to splicing at the 3' splice site.

RNA (New York, N.Y.) - 1 Aug 1996

Lin J, Rossi J J

Abstract excerpt

An experimentally introduced secondary structure in exon 2 adjacent to the 3' splice site of a yeast ACT-Escherichia coli lacZ fusion gene abolishes splicing in vivo and inhibits beta-galactosidase production. We have devised a genetic screen to isolate both cis and trans-acting mutants that restore beta-galactosidase activity. Two cis-acting mutants potentially destabilize the stem in the region close to the 3'...

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Identifiers

PMID: 8752092
PMCID: PMC1369419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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