Article
SSL1, a suppressor of a HIS4 5'-UTR stem-loop mutation, is essential for translation initiation and affects UV resistance in yeast.
Genes & development - 1 Dec 1992
Yoon H, Miller S P, Pabich E K, Donahue T F
Abstract excerpt
The SSL1 locus was identified as a trans-acting suppressor that restores HIS4 expression despite a stem-loop structure in the 5'-UTR. SSL1 encodes an essential protein of 52 kD with features characteristic of a protein with multiple zinc fingers. The mechanism of SSL1 suppression is not related to altering his4 transcription or removing the stem-loop sequence from the 5'-UTR; rather, 3- to 5-fold increases in...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA, Fungal
- Fungal Proteins
- Genes, Suppressor
- Molecular Sequence Data
- Phenotype
- Polyribosomes
- Protein Biosynthesis
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins