bcl-2 expression is reciprocal to p53 and c-myc expression in metastatic human colorectal cancer.

doi:10.1016/s0959-8049(98)00057-4

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Article

bcl-2 expression is reciprocal to p53 and c-myc expression in metastatic human colorectal cancer.

European journal of cancer (Oxford, England : 1990) - 1 Jul 1998

Popescu R A, Lohri A, de Kant E, Thiede C, Reuter J, Herrmann R, Rochlitz C F

Abstract excerpt

Apoptosis (programmed cell death) inhibition may be an important mechanism by which gastrointestinal mucosal cells containing damaged DNA evade normal clearance mechanisms and grow to become invasive tumours. Since bcl-2 is an apoptosis inhibitor, bcl-2 mRNA expression was measured in 21 metastas...

Topics

Apoptosis
Chromatography, High Pressure Liquid
Colorectal Neoplasms
Gene Expression
Genes, ras
Humans
Mutation
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-myc
RNA, Messenger
Reverse Transcriptase Polymerase Chain Reaction
Tumor Suppressor Protein p53

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PMID: 9849490
DOI: 10.1016/s0959-8049(98)00057-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9849490-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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