Stable expression of a secretable deletion mutant of recombinant human thrombomodulin in mammalian cells.

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Article

Stable expression of a secretable deletion mutant of recombinant human thrombomodulin in mammalian cells.

The Journal of biological chemistry - 25 Jul 1990

Parkinson J F, Grinnell B W, Moore R E, Hoskins J, Vlahos C J, Bang N U

Abstract excerpt

Thrombomodulin is an endothelial cell membrane protein which plays a central regulatory role in the protein C anticoagulant pathway. The human thrombomodulin intronless gene was isolated from a genomic DNA library and used to isolate the coding region. A mammalian expression vector, phd-TMD1, enc...

Topics

Amino Acids
Animals
Anticoagulants
Base Sequence
Calcium
Cells, Cultured
Chondroitin Lyases
Cricetinae
Glycoproteins
Humans
In Vitro Techniques
Kinetics
Molecular Sequence Data
Molecular Weight
Mutation
Oligonucleotide Probes
Protein C
Receptors, Cell Surface

Source

Open in PubMed

Identifiers

PMID: 2165069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2165069-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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