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Article

Thrombomodulin as a regulator of the anticoagulant pathway: implication in the development of thrombosis.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jan 2012

Anastasiou Georgia, Gialeraki Argyri, Merkouri Efrossyni, Politou Marianna, Travlou Anthi

Abstract excerpt

Thrombomodulin is a cell surface-expressed glycoprotein that serves as a cofactor for thrombin-mediated activation of protein C (PC), an event further amplified by the endothelial cell PC receptor. The PC pathway is a major anticoagulant mechanism that downregulates thrombin formation and hedges thrombus formation. The objectives of this review were to review recent findings regarding thrombomodulin structure,...

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Source

Identifiers

PMID: 22036808
DOI: 10.1097/MBC.0b013e32834cb271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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