Article
The short loop between epidermal growth factor-like domains 4 and 5 is critical for human thrombomodulin function.
The Journal of biological chemistry - 25 Mar 1993
Clarke J H, Light D R, Blasko E, Parkinson J F, Nagashima M, McLean K, Vilander L, Andrews W H, Morser J, Glaser C B
Abstract excerpt
Thrombomodulin (TM) is a cofactor for activation of protein C by thrombin. We showed that 80-90% of this cofactor activity is lost by oxidation of Met388, located within the short interdomain loop between epidermal growth factor-like domains 4 and 5 (Glaser, C. B., Morser, J., Clarke, J. H., Blas...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Calcium
- Cattle
- Cloning, Molecular
- DNA
- Epidermal Growth Factor
- Escherichia coli
- Humans
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Protein Structure, Secondary
- Receptors, Cell Surface
- Receptors, Thrombin
- Thrombin