Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation.

The Journal of cell biology - 1 Dec 1997

Zhang B, Tu P, Abtahian F, Trojanowski J Q, Lee V M

Abstract excerpt

Mice engineered to express a transgene encoding a human Cu/Zn superoxide dismutase (SOD1) with a Gly93 --> Ala (G93A) mutation found in patients who succumb to familial amyotrophic lateral sclerosis (FALS) develop a rapidly progressive and fatal motor neuron disease (MND) similar to amyotrophic lateral sclerosis (ALS). Hallmark ALS lesions such as fragmentation of the Golgi apparatus and neurofilament (NF)-rich...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Biological Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

Share to Disease Models, Animal

Share to Gene Dosage

Share to Mice, Transgenic

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 9382875
DOI: 10.1083/jcb.139.5.1307
PMCID: PMC2140205

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation.PMID 9382875Read ↗

Slow component of axonal transport is impaired in the proximal axon of transgenic mice with a G93A mutant SOD1 gene.Semantic proximity Read ↗

Aggregates of mutant protein appear progressively in dendrites, in periaxonal processes of oligodendrocytes, and in neuronal and astrocytic perikarya of mice expressing the SOD1(G93A) mutation of familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease.Semantic proximity Read ↗

Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.Semantic proximity Read ↗

Defective neurofilament transport in mouse models of amyotrophic lateral sclerosis: a review.Semantic proximity Read ↗

ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor NeuronsSemantic proximity Read ↗

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).Semantic proximity Read ↗

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.Semantic proximity Read ↗

Ultrastructural study of mitochondria in the spinal cord of transgenic mice with a G93A mutant SOD1 gene.Semantic proximity Read ↗

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease.Semantic proximity Read ↗

Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neuronsSemantic proximity Read ↗

A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.