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Article

A role for neurofilaments in the pathogenesis of amyotrophic lateral sclerosis.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jan 2000

Julien J P

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a late-onset degenerative disease of motor neurons, characterized by abnormal accumulation of neurofilaments (NFs) in perikarya and proximal axons. Two lines of evidence suggest that neurofilament accumulation can play a crucial role in ALS pathogenesis. First, transgenic mouse models overexpressing NF proteins were found to develop motor neuron degeneration and, second,...

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Identifiers

PMID: 8714677
DOI: 10.1139/o95-064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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A role for neurofilaments in the pathogenesis of amyotrophic lateral sclerosis.PMID 8714677Read ↗

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New perspectives on cytoskeletal dysregulation and mitochondrial mislocalization in amyotrophic lateral sclerosisSemantic proximity Read ↗

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Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosisSemantic proximity Read ↗

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