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Article

A role for neurofilaments in the pathogenesis of amyotrophic lateral sclerosis.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Jan 2000

Julien J P

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a late-onset degenerative disease of motor neurons, characterized by abnormal accumulation of neurofilaments (NFs) in perikarya and proximal axons. Two lines of evidence suggest that neurofilament accumulation can play a crucial role in ALS pathogenesis. Fir...

Topics

Alleles
Amyotrophic Lateral Sclerosis
Animals
Axonal Transport
Gene Expression Regulation
Genetic Variation
Humans
Mice
Mice, Transgenic
Neurofilament Proteins
Structure-Activity Relationship

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8714677
DOI: 10.1139/o95-064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8714677-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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