Article
Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants.
Development (Cambridge, England) - 1 Oct 1994
Lohnes D, Mark M, Mendelsohn C, Dollé P, Dierich A, Gorry P, Gansmuller A, Chambon P
Abstract excerpt
Numerous congenital malformations have been observed in fetuses of vitamin A-deficient (VAD) dams [Wilson, J. G., Roth, C. B., Warkany, J., (1953), Am. J. Anat. 92, 189-217]. Previous studies of retinoic acid receptor (RAR) mutant mice have not revealed any of these malformations [Li, E., Sucov,...
Topics
- Abnormalities, Multiple
- Animals
- Bone and Bones
- Brain
- Extremities
- Eye
- Eye Abnormalities
- Facial Bones
- Genotype
- Limb Deformities, Congenital
- Mice
- Mice, Mutant Strains
- Morphogenesis
- Phenotype
- Receptors, Retinoic Acid
- Skull
- Tretinoin