The use of dominant-negative mutations to elucidate signal transduction pathways in lymphocytes.

doi:10.1016/s0952-7915(96)80069-0

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Article

The use of dominant-negative mutations to elucidate signal transduction pathways in lymphocytes.

Current opinion in immunology - 1 Apr 1996

Perlmutter R M, Alberola-Ila J

Abstract excerpt

Recent publications document an exponential increase in the use of dominant-negative mutations as tools for the experimental dissection of lymphocyte signaling pathways. This approach may be the only one available for in vitro analysis of cell lines. Moreover, when implemented in transgenic anima...

Topics

Animals
Genetic Engineering
Lymphocytes
Mutation
Signal Transduction

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