Article
Advances in targeting signal transduction pathways.
Oncotarget - 1 Dec 2012
McCubrey James A, Steelman Linda S, Chappell William H, Sun Lin, Davis Nicole M, Abrams Stephen L, Franklin Richard A, Cocco Lucio, Evangelisti Camilla, Chiarini Francesca, Martelli Alberto M, Libra Massimo, Candido Saverio, Ligresti Giovanni, Malaponte Grazia, Mazzarino Maria C, Fagone Paolo, Donia Marco, Nicoletti Ferdinando, Polesel Jerry, Talamini Renato, Bäsecke Jörg, Mijatovic Sanja, Maksimovic-Ivanic Danijela, Michele Michele, Tafuri Agostino, Dulińska-Litewka Joanna, Laidler Piotr, D'Assoro Antonio B, Drobot Lyudmyla, Umezawa Drobot, Montalto Giuseppe, Cervello Melchiorre, Demidenko Zoya N
Abstract excerpt
Over the past few years, significant advances have occurred in both our understanding of the complexity of signal transduction pathways as well as the isolation of specific inhibitors which target key components in those pathways. Furthermore critical information is being accrued regarding how genetic mutations can affect the sensitivity of various types of patients to targeted therapy. Finally, genetic...
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