Usage of activating mutations in the analysis of cytokine signal transduction pathways.

doi:10.1016/s0925-5710(98)00009-7

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Article

Usage of activating mutations in the analysis of cytokine signal transduction pathways.

International journal of hematology - 1 Apr 1998

Onishi M

Abstract excerpt

Cytokine signal transduction pathways are highly redundant and complex. The analysis of the structure and function of signal transduction molecules was conventionally done by using mutated or truncated receptors, dominant negative molecules, and knockout mice. These methods are designed to look a...

Topics

Animals
Cytokines
DNA Mutational Analysis
Gene Targeting
Humans
Mice
Mutation
Signal Transduction

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