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Article

The influence of apolipoprotein E phenotype on the response to lovastatin therapy in patients with heterozygous familial hypercholesterolemia.

Metabolism: clinical and experimental - 1 Feb 1990

O'Malley J P, Illingworth D R

Abstract excerpt

Apolipoprotein E (apo E) phenotypes have been previously shown to influence plasma lipoprotein concentrations in normal populations and to affect the response to some lipid lowering drugs. The purpose of the present study was to determine if variations in the apo E phenotype also affect basal lip...

Topics

Adult
Aged
Apolipoproteins E
Cholesterol, HDL
Cholesterol, LDL
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Heterozygote
Humans
Hyperlipoproteinemia Type II
Lipids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipoproteins

Lovastatin

Male

Middle Aged

Phenotype

Source

Identifiers

PMID: 2299987
DOI: 10.1016/0026-0495(90)90068-n

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2299987-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The influence of apolipoprotein E phenotype on the response to lovastatin therapy in patients with heterozygous familial hypercholesterolemia.PMID 2299987Read ↗

Apolipoprotein E phenotypes in familial hypercholesterolaemia: importance for expression of disease and response to therapy.Semantic proximity Read ↗

The response to lovastatin treatment in patients with heterozygous familial hypercholesterolemia is modulated by apolipoprotein E polymorphism.Semantic proximity Read ↗

Apolipoprotein E polymorphism and heterozygous familial hypercholesterolemia. Sex-specific effects.Semantic proximity Read ↗

Effect of apolipoprotein E genotype on lipid levels and response to diet in familial hypercholesterolemia.Semantic proximity Read ↗

The effect of apolipoprotein E polymorphism on the response to lipid-lowering treatment with atorvastatin or fenofibrate.Semantic proximity Read ↗

Influence of apo E polymorphism on the response to simvastatin treatment in patients with heterozygous familial hypercholesterolemia.Semantic proximity Read ↗

Apolipoprotein E polymorphism and atherosclerosis.Semantic proximity Read ↗

Effect of apoE genotype on the hypolipidaemic response to pravastatin in an outpatient setting.Semantic proximity Read ↗

Pharmacogenetics of Apolipoprotein E Gene During Lipid-Lowering Therapy: Lipid Levels and Prevention of Coronary Heart DiseaseSemantic proximity Read ↗

Effects of apolipoprotein E phenotype on serum cholesterol level and cholesterol response to diet therapy in patients with hypercholesterolemia.Semantic proximity Read ↗

Association of apolipoprotein (Apo)E genotype with plasma apo E levels.Semantic proximity Read ↗

Prevalence of apolipoprotein E phenotypes in ischemic cerebrovascular disease. A case-control study.Semantic proximity Read ↗

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