Article
Type III dyslipoproteinemia in patients heterozygous for familial hypercholesterolemia and apolipoprotein E2. Evidence for a gene-gene interaction.
Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Jan 2000
Hopkins P N, Wu L L, Schumacher M C, Emi M, Hegele R M, Hunt S C, Lalouel J M, Williams R R
Abstract excerpt
In four large pedigrees with heterozygous familial hypercholesterolemia (FH) genetically linked to the low density lipoprotein receptor locus, we have observed a strong interaction between the presence of FH and a single apolipoprotein (apo) E2 allele, resulting in a markedly increased prevalence of type III dyslipoproteinemia (DLPIII). DLPIII was defined by chemical criteria. None of the patients with DLPIII had...
Topics
- Adolescent
- Adult
- Age Factors
- Aged
- Apolipoprotein E2
- Apolipoproteins E
- Body Mass Index
- Child
- Child, Preschool
- Cholesterol, LDL
- Cholesterol, VLDL