Article
YAC transgenesis in farm animals: rescue of albinism in rabbits.
Molecular reproduction and development - 1 May 1996
Brem G, Besenfelder U, Aigner B, Müller M, Liebl I, Schütz G, Montoliu L
Abstract excerpt
The generation of transgenic mice with mammalian genes cloned in yeast artificial chromosomes (YACs) has generated great interest in the field of gene transfer into livestock. Many of the problems associated with standard transgenesis-such as lack of crucial regulator elements and position effects related to the integration site, which lead to variation in expression levels irrespective of the dose of the...
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