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Article

Constrained evolvability of interferon suppression in an RNA virus.

Scientific reports - 21 Apr 2016

Garijo Raquel, Cuevas José M, Briz Álvaro, Sanjuán Rafael

Abstract excerpt

Innate immunity responses controlled by interferon (IFN) are believed to constitute a major selective pressure shaping viral evolution. Viruses encode a variety of IFN suppressors, but these are often multifunctional proteins that also play essential roles in other steps of the viral infection cycle, possibly limiting their evolvability. Here, we experimentally evolved a vesicular stomatitis virus (VSV) mutant...

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Source

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Identifiers

PMID: 27098004
DOI: 10.1038/srep24722
PMCID: PMC4838867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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