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Article

Dual Role of alpha6beta4 integrin in epidermal tumor growth: tumor-suppressive versus tumor-promoting function.

Molecular biology of the cell - 1 Nov 2007

Raymond Karine, Kreft Maaike, Song Ji-Ying, Janssen Hans, Sonnenberg Arnoud

Abstract excerpt

An increased expression of the integrin alpha6beta4 is correlated with a poor prognosis in patients with squamous cell carcinomas. However, little is known about the role of alpha6beta4 in the early stages of tumor development. We have isolated cells from mouse skin (mouse tumor-initiating cells [mTICs]) that are deficient in both p53 and Smad4 and carry conditional alleles of the beta4 gene (Itgb4). The mTICs...

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Identifiers

PMID: 17699601
DOI: 10.1091/mbc.e06-08-0720
PMCID: PMC2043572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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