Integrin mutations in blistering skin diseases and related genetically engineered mouse models.

Abstract excerpt

As major receptors for cellular adhesion, integrins in the epidermis are critical to maintain skin integrity. Integrins α6β4 and α3β1 are among the most highly and widely expressed integrins in the skin. Perhaps not surprisingly, mutation in subunits associated with these integrins cause variations of a blistering skin disease called junctional epidermolysis bullosa (JEB), which is characterized by blisters that...

Topics

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• Blister
• Disease Models, Animal
• Epidermis
• Epidermolysis Bullosa, Junctional
• Integrins