Article
Endoplasmic reticulum localization of Sec12p is achieved by two mechanisms: Rer1p-dependent retrieval that requires the transmembrane domain and Rer1p-independent retention that involves the cytoplasmic domain.
The Journal of cell biology - 1 Jul 1996
Sato M, Sato K, Nakano A
Abstract excerpt
Yeast Sec12p is a type II transmembrane protein in the ER, which is essential for the formation of transport vesicles. From biochemical and morphological lines of evidence, we have proposed that Sec12p is localized to the ER by two mechanisms: static retention in the ER and dynamic retrieval from...
Topics
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- Cloning, Molecular
- Cytoplasm
- DNA, Fungal
- Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
- Endoplasmic Reticulum
- Fungal Proteins
- Guanine Nucleotide Exchange Factors
- Mannose
- Membrane Glycoproteins
- Membrane Proteins