Article
Rer1p, a retrieval receptor for ER membrane proteins, recognizes transmembrane domains in multiple modes.
Molecular biology of the cell - 1 Sept 2003
Sato Ken, Sato Miyuki, Nakano Akihiko
Abstract excerpt
The yeast Golgi membrane protein Rer1p is required for the retrieval of various endoplasmic reticulum (ER) membrane proteins such as Sec12p and Sec71p to the ER. We demonstrate here that the transmembrane domain (TMD) of Sec71p, a type-III membrane protein, contains an ER localization signal, which is required for physical recognition by Rer1p. The Sec71TMD-GFP fusion protein is efficiently retrieved to the ER by...
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