Sec12p requires Rer1p for sorting to coatomer (COPI)-coated vesicles and retrieval to the ER.

doi:10.1242/jcs.110.8.991

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Article

Sec12p requires Rer1p for sorting to coatomer (COPI)-coated vesicles and retrieval to the ER.

Journal of cell science - 1 Apr 1997

Boehm J, Letourneur F, Ballensiefen W, Ossipov D, Démollière C, Schmitt H D

Abstract excerpt

In Saccharomyces cerevisiae cells lacking the Rer1 protein (Rer1p), the type II transmembrane protein Sec12p fails to be retained in the ER. The transmembrane domain of Sec12p is sufficient to confer Rer1p-dependent ER retention to other membrane proteins. In rer1 mutants a large part of the Sec1...

Topics

Coatomer Protein
Cytoplasmic Granules
Endoplasmic Reticulum
Fungal Proteins
Guanine Nucleotide Exchange Factors
Membrane Glycoproteins
Membrane Proteins
Mutation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Vesicular Transport Proteins

Source

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Identifiers

PMID: 9152025
DOI: 10.1242/jcs.110.8.991

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9152025-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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