Genotypic selection of mitochondrial and oncogenic mutations in human tissue suggests mechanisms of age-related pathophysiology.

doi:10.1016/0921-8734(95)00020-7

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Article

Genotypic selection of mitochondrial and oncogenic mutations in human tissue suggests mechanisms of age-related pathophysiology.

Mutation research - 1 Oct 1995

Cortopassi G, Liu Y

Abstract excerpt

The invention of the polymerase chain reaction (PCR) has facilitated the development of a new class of assays to quantify human somatic mutations in vivo, based on genotypic selection of mutants at the DNA level rather than phenotypic selection of mutants at the cell level. Use of these assays ha...

Topics

Aging
Apoptosis
Brain
Chromosomes, Human
DNA, Mitochondrial
Genotype
Humans
Mutation
Neoplasms
Oncogenes
Parkinson Disease

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