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Article

Epidermal growth factor and platelet-derived growth factor regulate the activity of the insulin-like growth factor I gene promoter.

Experimental gerontology - 1 Jan 2000

Li S, Baserga R

Abstract excerpt

The expression of insulin-like growth factor I (IGF-I) is regulated by hormones, oncogenes, and other growth factors, and is markedly decreased or even absent in senescent human diploid fibroblasts. In previous articles, we have reported that the SV40 large T antigen increases the production of IGF-I and that the expression of the IGF-I gene is negatively regulated by an E2F binding site in the IGF-I promoter. We...

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PMID: 8706788
DOI: 10.1016/0531-5565(95)02011-x

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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