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Article

Morphological study of disordered myelination and the degeneration of nerve fibers in the spinal cord of mice lacking complex gangliosides.

Archives of histology and cytology - 1 Mar 2003

Ma Qian, Kobayashi Miya, Sugiura Midori, Ozaki Noriyuki, Nishio Koji, Shiraishi Yosuke, Furukawa Keiko, Furukawa Koichi, Sugiura Yasuo

Abstract excerpt

Gangliosides, a family of glycosphingolipids that contain sialic acid, are abundant on the neuronal cell membranes, but their precise functions in the central nervous system remain largely undefined. In a previous study of GalNAc-T(-/-) mice engineered to lack beta1,4-N-acetylgalactos-aminyltransferase (GM2/GD2 synthase) to abolish any, complex gangliosides, we observed the reduction of nerve conduction velocity...

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PMID: 12703552
DOI: 10.1679/aohc.66.37

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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