Article
The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production.
The Biochemical journal - 15 Feb 2009
Teijeira Fernando, Ullán Ricardo V, Guerra Susana M, García-Estrada Carlos, Vaca Inmaculada, Martín Juan F
Abstract excerpt
The cluster of early cephalosporin biosynthesis genes (pcbAB, pcbC, cefD1, cefD2 and cefT of Acremonium chrysogenum) contains all of the genes required for the biosynthesis of the cephalosporin biosynthetic pathway intermediate penicillin N. Downstream of the cefD1 gene, there is an unassigned open reading frame named cefM encoding a protein of the MFS (major facilitator superfamily) with 12 transmembrane...
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