Article
Enhanced expression of the mannose receptor by endothelial cells of the liver and spleen microvascular beds in the macrophage-deficient PU.1 null mouse.
Histochemistry and cell biology - 1 Jun 2005
Linehan Sheena A, Weber Roberta, McKercher Scott, Ripley Ruth M, Gordon Siamon, Martin Paul
Abstract excerpt
Mice null for the haematopoietic lineage-specific transcription factor PU.1 lack mature Mphi and are compromised in their ability to clear cellular debris from the blood circulation. We investigated the possibility that non-professional phagocytes may partially compensate for the lack of Mphi in clearance functions. In the absence of Kupffer cells (resident liver Mphi) in the PU.1 null mice, electron microscopy...
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