Article
[Molecular analysis of the estrogen receptor (ER) gene in association with ER negativity in breast cancer].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Mar 1996
Iwase H, Kobayashi S, Iwata H, Yamashita T, Ito K, Toyama T, Hara Y, Greenman J, Mathew C G
Abstract excerpt
DNA from ninety-eight primary breast cancer biopsies has been examined for loss of heterozygosity (LOH). Thirteen of seventy-two informative cases (18.1%) were positive for LOH, which correlated with age at operation but not with ER status. This result suggests that LOH of the ER gene does not have an important role in the lack of ER function in breast cancer tissues. Thirteen breast cancers with ER...
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