Article
Analysis of the PvuII restriction fragment-length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood.
Cancer research - 1 Jan 1992
Yaich L, Dupont W D, Cavener D R, Parl F F
Abstract excerpt
The presence of estrogen receptor (ER) is a well-known predictor of clinical outcome in human breast cancer. We examined the ER gene in 26 primary breast cancers (14 ER-positive, 12 ER-negative) to determine if alterations of the gene are associated with the ER-negative status. In tumor biopsies...
Topics
- Adult
- Alleles
- Base Sequence
- Breast Neoplasms
- Deoxyribonucleases, Type II Site-Specific
- Exons
- Female
- Humans
- Middle Aged
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Receptors, Estrogen