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Article

Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication.

The EMBO journal - 23 Mar 2005

O'Shea Clodagh, Klupsch Kristina, Choi Serah, Bagus Bridget, Soria Conrado, Shen Jerry, McCormick Frank, Stokoe David

Abstract excerpt

Like tumor cells, DNA viruses have had to evolve mechanisms that uncouple cellular replication from the many intra- and extracellular factors that normally control it. Here we show that adenovirus encodes two proteins that activate the mammalian target of rapamycin (mTOR) for viral replication, e...

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Source

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Identifiers

PMID: 15775987
DOI: 10.1038/sj.emboj.7600597
PMCID: PMC556401

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-15775987-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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