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Human Papillomavirus Type 16 E7 Maintains Elevated Levels of the cdc25A Tyrosine Phosphatase during Deregulation of Cell Cycle Arrest

15 Jan 2002

Abstract excerpt

Essential to the oncogenic properties of human papillomavirus type 16 (HPV-16) are the activities encoded by the early gene product E7. HPV-16 E7 (E7.16) binds to cellular factors involved in cell cycle regulation and differentiation. These include the retinoblastoma tumor suppressor protein (Rb) and histone deacetylase (HDAC) complexes. While the biological significance of these interactions remains unclear, E7...

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Cervical Cancer and HPV Research
interferon and immune responses
Viral-associated cancers and disorders

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11752153
DOI: 10.1128/jvi.76.2.619-632.2002

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Human Papillomavirus Type 16 E7 Maintains Elevated Levels of the cdc25A Tyrosine Phosphatase during Deregulation of Cell Cycle ArrestPMID 11752153Read ↗

Human papillomavirus type 16 E7 oncoprotein associates with E2F6.Semantic proximity Read ↗

Interactions with Pocket Proteins Contribute to the Role of Human Papillomavirus Type 16 E7 in the Papillomavirus Life CycleSemantic proximity Read ↗

The E7 Open Reading Frame Acts in cis and in trans To Mediate Differentiation-Dependent Activities in the Human Papillomavirus Type 16 Life CycleSemantic proximity Read ↗

Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoproteinSemantic proximity Read ↗

Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinaseSemantic proximity Read ↗

New Concepts on the Role of Human Papillomavirus in Cell Cycle RegulationSemantic proximity Read ↗

Induction of pRb Degradation by the Human Papillomavirus Type 16 E7 Protein Is Essential To Efficiently Overcome p16 <sup>INK4a</sup> -Imposed G <sub>1</sub> Cell Cycle ArrestSemantic proximity Read ↗

Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathwaySemantic proximity Read ↗

Human Papillomavirus Type 16 E1 ∧ E4-Induced G 2 Arrest Is Associated with Cytoplasmic Retention of Active Cdk1/Cyclin B1 ComplexesSemantic proximity Read ↗

Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways.Semantic proximity Read ↗

PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesisSemantic proximity Read ↗

Examination of the pRb-Dependent and pRb-Independent Functions of E7 In VivoSemantic proximity Read ↗

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