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Article

Abnormal splicing of the leptin receptor in diabetic mice.

Nature - 15 Feb 1996

Lee G H, Proenca R, Montez J M, Carroll K M, Darvishzadeh J G, Lee J I, Friedman J M

Abstract excerpt

Mutations in the mouse diabetes (db) gene result in obesity and diabetes in a syndrome resembling morbid human obesity. Previous data suggest that the db gene encodes the receptor for the obese (ob) gene product, leptin. A leptin receptor was recently cloned from choroid plexus and shown to map t...

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Identifiers

PMID: 8628397
DOI: 10.1038/379632a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8628397-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormal splicing of the leptin receptor in diabetic mice.PMID 8628397Read ↗

Defective STAT signaling by the leptin receptor in diabetic mice.Semantic proximity Read ↗

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.Semantic proximity Read ↗

Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice.Semantic proximity Read ↗

Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus.Semantic proximity Read ↗

[The "diabetes" (db) gene of the mouse codes for a mutated leptin receptor--a cue to understanding obesity?].Semantic proximity Read ↗

Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor.Semantic proximity Read ↗

Metabolic characterization of a mouse deficient in all known leptin receptor isoforms.Semantic proximity Read ↗

[The research applications of db/db mouse].Semantic proximity Read ↗

A novel and quick PCR-based method to genotype mice with a leptin receptor mutation (db/db mice).Semantic proximity Read ↗

New leptin receptor mutations in mice: Lepr(db-rtnd), Lepr(db-dmpg) and Lepr(db-rlpy).Semantic proximity Read ↗

Leptin receptor mutations in 129 db3J/db3J mice and NIH facp/facp rats.Semantic proximity Read ↗

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.Semantic proximity Read ↗

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