Article
N-terminomics identifies widespread endoproteolysis and novel methionine excision in a genome-reduced bacterial pathogen
5 Sept 2017
Abstract excerpt
Proteolytic processing alters protein function. Here we present the first systems-wide analysis of endoproteolysis in the genome-reduced pathogen Mycoplasma hyopneumoniae. 669 N-terminal peptides from 164 proteins were identified, demonstrating that functionally diverse proteins are processed, more than half of which 75 (53%) were accessible on the cell surface. Multiple cleavage sites were characterised, but...
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