Article
Absence of glomerular IgA1 deposition despite overexpression of galactose-deficient IgA1 in the B cell c1galt1 knockout mouse.
Kidney international - 1 Sept 2026
Wu Jingyi, Xie Tong, Zhang Zhao, Liu Xingzi, Zhou Xujie, Zhang Yong, Tian Wenmin, Gale Daniel P, Zhu Shu, Barratt Jonathan, Jin Jing, Zhang Yuemiao, Zhang Hong, Lv Jicheng
Abstract excerpt
INTRODUCTION: Aberrant O-linked glycosylation of the IgA hinge segment resulting in galactose-deficient IgA1 (Gd-IgA1) is frequently observed in patients with IgA nephropathy (IgAN), and it is hypothesized to be pathogenic. Here, we genetically disrupted the expression of galactosyltransferase 1 (C1galt1) to elevate Gd-IgA1 levels in mice and examine its role in glomerular deposition. METHODS: We previously...
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