Article
DNA analysis of the immunoglobulin IGHG loci in a Mandenka population from eastern Senegal: correlation with Gm haplotypes and hypotheses for the evolution of the Ig CH region.
Human genetics - 1 Jul 1996
Dard P, Sanchez-Mazas A, Dugoujon J M, De Lange G, Langaney A, Lefranc M P, Lefranc G
Abstract excerpt
This study presents restriction fragment length polymorphism (RFLP) and serological analyses of the immunoglobulin CH loci in a sample of 100 individuals from a Senegalese Mandenka population. The RFLP variability is mostly the result of large DNA insertions or deletions in the non-coding flankin...
Topics
- Alleles
- Chromosomes, Human, Pair 14
- Evolution, Molecular
- Gene Frequency
- Genes, Immunoglobulin
- Genetic Linkage
- Haplotypes
- Humans
- Immunoglobulin Allotypes
- Immunoglobulin Constant Regions
- Immunoglobulin Gm Allotypes
- Immunoglobulin Heavy Chains
- Linkage Disequilibrium
- Polymorphism, Genetic