Article
Human Immunoglobulin Heavy Gamma Chain Polymorphisms: Molecular Confirmation Of Proteomic Assessment.
Molecular & cellular proteomics : MCP - 1 May 2017
Dambrun Magalie, Dechavanne Célia, Emmanuel Alexandra, Aussenac Florentin, Leduc Marjorie, Giangrande Chiara, Vinh Joëlle, Dugoujon Jean-Michel, Lefranc Marie-Paule, Guillonneau François, Migot-Nabias Florence
Abstract excerpt
Immunoglobulin G (IgG) proteins are known for the huge diversity of the variable domains of their heavy and light chains, aimed at protecting each individual against foreign antigens. The IgG also harbor specific polymorphism concentrated in the CH2 and CH3-CHS constant regions located on the Fc fragment of their heavy chains. But this individual particularity relies only on a few amino acids among which some...
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