Article
Variability of the immunoglobulin heavy chain constant region locus: a population study.
Human genetics - 1 Mar 1995
Brusco A, Cariota U, Bottaro A, Boccazzi C, Plebani A, Ugazio A G, Galanello R, Guerra M G, Carbonara A O
Abstract excerpt
The Immunoglobulin Heavy chain Constant region (IGHC) locus is a multigene family composed of highly homologous segments often involved in unequal crossings over that lead to deleted and duplicated haplotypes. The frequencies of these haplotypes in 558 individuals from Lombardy, Veneto, Puglia and Sardinia were determined by Pulsed Field Gel Electrophoresis (PFGE), followed by Southern blotting with four IGHC...
Topics
- Blotting, Southern
- Crossing Over, Genetic
- Electrophoresis, Gel, Pulsed-Field
- Gene Frequency
- Gene Rearrangement
- Genetic Variation
- Haplotypes
- Humans
- Immunoglobulin Constant Regions
- Immunoglobulin Heavy Chains