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Article

Gene segments encoding membrane domains of the human immunoglobulin gamma 3 and alpha chains.

Immunogenetics - 1 Jan 1990

Bensmana M, Lefranc M P

Abstract excerpt

The carboxyterminal region of the heavy chains, according to its hydrophilic or hydrophobic properties, determines whether the immunoglobulin will be secreted or membrane-bound. We have determined the nucleotide sequences of the human IGHG3, IGHA1, and IGHA2 membrane exons isolated from genomic DNA libraries. The IGHG3 M1 and M2 exons are separated by a long intron of 2.1 kilobases (kb) containing an highly...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Cloning, Molecular
Exons
Gene Library
Humans
Immunoglobulin G
Immunoglobulin Heavy Chains
Immunoglobulin alpha-Chains
Immunoglobulin gamma-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Polymorphism, Restriction Fragment Length

Receptors, Antigen, B-Cell

Restriction Mapping

Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 1979064
DOI: 10.1007/BF00211646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1979064-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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