Article
Hotspot variation at the CH2-CH3 interface of leporid IgG antibodies (Oryctolagus, Sylvilagus and Lepus).
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Dec 2002
Esteves P J, Alves P C, Ferrand N, van der Loo W
Abstract excerpt
The European rabbit (Oryctolagus cuniculus) is the only species known to express only one subclass of gamma class immunoglobulin (IgG) antibodies. The rabbit IGHGCH2 (second domain of the gene region encoding the IgG heavy chain constant region) or e locus presents two serologically defined alleles, the e14 and e15 allotypes. These are correlated with amino acid variation at position 309, which is located within...
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