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Article

Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling.

Cell - 14 Jun 1996

Herbst R, Carroll P M, Allard J D, Schilling J, Raabe T, Simon M A

Abstract excerpt

The SH2 domain-containing phosphotyrosine phosphatase Corkscrew (CSW) is an essential component of the signaling pathway initiated by the activation of the sevenless receptor tyrosine kinase (SEV) during Drosophila eye development. We have used genetic and biochemical approaches to identify a substrate for CSW. Expression of a catalytically inactive CSW was used to trap CSW in a complex with a 115 kDa...

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PMID: 8681384
DOI: 10.1016/s0092-8674(00)81273-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling.PMID 8681384Read ↗

The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf.Semantic proximity Read ↗

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Signaling by ectopically expressed Drosophila Src64 requires the protein-tyrosine phosphatase corkscrew and the adapter downstream of receptor kinases.Semantic proximity Read ↗

Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila.Semantic proximity Read ↗

Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.Semantic proximity Read ↗

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Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila.Semantic proximity Read ↗

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Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.Semantic proximity Read ↗

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