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Article

Linkage and association studies in insulin-dependent diabetes with a new dinucleotide repeat polymorphism at the GAD65 locus.

Autoimmunity - 1 Jan 1995

Wapelhorst B, Bell G I, Risch N, Spielman R S, Concannon P

Abstract excerpt

Glutamic acid decarboxylase (GAD) is an important autoantigen in insulin-dependent diabetes mellitus (IDDM). The islet cell specific, 65 kDa form of GAD (GAD65) is encoded by a gene on chromosome 10p. Recently, a putative IDDM susceptibility gene has been localized to the same general region based on allele sharing for the anonymous marker D10S193. To determine whether variation in the GAD65 gene plays a role in...

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Identifiers

PMID: 8679901
DOI: 10.3109/08916939508993360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Linkage and association studies in insulin-dependent diabetes with a new dinucleotide repeat polymorphism at the GAD65 locus.PMID 8679901Read ↗

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Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.Semantic proximity Read ↗

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.Semantic proximity Read ↗

CD4+ and CD8+ T-cell clones from congenital rubella syndrome patients with IDDM recognize overlapping GAD65 protein epitopes. Implications for HLA class I and II allelic linkage to disease susceptibility.Semantic proximity Read ↗

Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding.Semantic proximity Read ↗

Conformation-dependent GAD65 autoantibodies in diabetes.Semantic proximity Read ↗

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