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Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage

17 Jun 2009

Abstract excerpt

BACKGROUND: P53 is a key tumor suppressor protein. In response to DNA damage, p53 accumulates to high levels in differentiated cells and activates target genes that initiate cell cycle arrest and apoptosis. Since stem cells provide the proliferative cell pool within organisms, an efficient DNA damage response is crucial. RESULTS: In proliferating embryonic stem cells, p53 is localized predominantly in the...

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PMID: 19534768
DOI: 10.1186/1471-2121-10-46

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