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Article

p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53.

Cell death & disease - 26 Feb 2015

Yan H, Solozobova V, Zhang P, Armant O, Kuehl B, Brenner-Weiss G, Blattner C

Abstract excerpt

Since it was found that p53 is highly expressed in murine embryonic stem cells, it remained a mystery whether p53 is active in this cell type. We show that a significant part of p53 is localised in the nucleus of murine embryonic stem cells and that the majority of this nuclear p53 is bound to DNA. According to its nuclear localisation, we show that p53 alters the transcriptional program of stem cells....

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Identifiers

PMID: 25719246
DOI: 10.1038/cddis.2015.33
PMCID: PMC4669809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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