Article
The use of compound heterozygotes and Hprt selection to analyze X-linked mottled alleles associated with prenatal lethality.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jul 1996
Masson W, Holt S, Reed V, Boyd Y
Abstract excerpt
X-linked mutant alleles associated with prenatal male lethality are difficult to analyze because only heterozygous females are readily available for study. Genomic analysis of the mutant allele is facilitated by the construction of somatic cell hybrids because this enables the segregation of the X Chromosomes (Chrs) that carry the mutant and wild-type alleles. We describe here a method that ensures that the X Chr...
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