Article
Identification of recessive maternal-effect mutations in the zebrafish using a gynogenesis-based method.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2004
Pelegri Francisco, Dekens Marcus P S, Schulte-Merker Stefan, Maischein Hans-Martin, Weiler Catrin, Nüsslein-Volhard Christiane
Abstract excerpt
In animal species, early developmental processes are driven by maternally derived factors. Here, we describe a forward genetics approach to identify recessive mutations in genes encoding such maternal factors in the zebrafish. We used a gynogenesis-based approach to identify 14 recessive maternal-effect mutations. Homozygosity for these mutations in adult females leads to the inviability of their offspring....
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