Article
Phenotype of B cells responding to the thymus-independent type-2 antigen polyvinyl pyrrolidinone.
International immunology - 1 Apr 1996
Whitmore A C, Haughton G, Arnold L W
Abstract excerpt
We have determined the origin and cell surface phenotype of B cells producing antibody in response to immunization with the non-self TI-2 antigen polyvinyl pyrrolidinone (PVP). We report that the responding cells are derived from precursors in adult bone marrow and display the phenotype characteristic of B-1 cells. By use of allotype marked chimeric mice, constructed by reconstituting lethally irradiated...
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