Article
T-independent and T-dependent B lymphoblasts: helper T cells prime for interleukin 2-induced growth and secretion of immunoglobulins that utilize downstream heavy chains.
The Journal of experimental medicine - 1 Mar 1991
Forman M S, Puré E
Abstract excerpt
Resting B cells enlarge, enter the cell cycle, and change their surface phenotype when activated via the surface immunoglobulin (Ig) receptor, but subsequent cell growth and antibody production is relatively limited. To identify stimuli that might prime B cells for enhanced function in vitro, we...
Topics
- Animals
- Antibody Formation
- Antigens, Surface
- B-Lymphocytes
- Cell Cycle
- Cells, Cultured
- Dendritic Cells
- Immunoglobulins
- Interferon-gamma
- Interleukin-1
- Interleukin-2
- Kinetics
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Phenotype
- Receptors, Interleukin-2